Immunogen
Synthesized peptide derived from human AP4A AA range: 93-143
Specificity
This antibody detects endogenous levels of AP4A at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011],
Function
catalytic activity:P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H(2)O = GTP + GMP.,cofactor:Divalent ions.,function:Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.,similarity:Belongs to the Nudix hydrolase family.,
Fields
>>Purine metabolism;>>Pyrimidine metabolism;>>Metabolic pathways
Human protein sequence Database
P50583
Mouse protein sequence database
P56380
Rat protein sequence database
Q6PEC0
Cellular localization
mitochondrial matrix,
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车