Immunogen
Synthesized peptide derived from human BTBD1 AA range: 115-165
Specificity
This antibody detects endogenous levels of BTBD1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Function
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 BTB (POZ) domain.,subcellular location:Cytoplasmic bodies.,subunit:Interacts with topoisomerase 1 and with TRIM5 isoform Delta. Interacts with CUL3.,tissue specificity:Ubiquitous; higher levels in heart and skeletal muscle.,
Gene Name
BTBD1 C15orf1 NS5ATP8
Human protein sequence Database
Q9H0C5
Mouse protein sequence database
P58544
Rat protein sequence database
Cellular localization
Cytoplasm . Localizes to punctate or elongated cytoplasmic bodies. .
Tissue expression
Ubiquitous; highest levels in testes, heart and skeletal muscle.
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