Immunogen
Synthesized peptide derived from human UCKL1 AA range: 223-273
Specificity
This antibody detects endogenous levels of UCKL1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014],
Function
catalytic activity:ATP + cytidine = ADP + CMP.,catalytic activity:ATP + uridine = ADP + UMP.,function:May contribute to UTP accumulation needed for blast transformation and proliferation.,pathway:Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.,pathway:Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.,PTM:Ubiquitinated by RNF19B; which induces proteasomal degradation.,similarity:Belongs to the uridine kinase family.,subcellular location:EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location.,subunit:Interacts with RNF19B and EBV EBNA3.,tissue specificity:Ubiquitous.,
Gene Name
UCKL1 URKL1 F538
Fields
>>Pyrimidine metabolism;>>Drug metabolism - other enzymes;>>Metabolic pathways;>>Nucleotide metabolism
Human protein sequence Database
Q9NWZ5
Mouse protein sequence database
Q91YL3
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location.
Tissue expression
Ubiquitous.
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