Immunogen
Synthesized peptide derived from human FBXL4 AA range: 396-446
Specificity
This antibody detects endogenous levels of FBXL4 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
Function
similarity:Contains 1 F-box domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Part of a SCF (SKP1-cullin-F-box) protein ligase complex.,tissue specificity:Expressed in heart, kidney, liver, lung, pancreas, and placenta, but not in skeletal muscle.,
Gene Name
FBXL4 FBL4 FBL5
Human protein sequence Database
Q9UKA2
Mouse protein sequence database
Q8BH70
Rat protein sequence database
Cellular localization
Cytoplasm. Nucleus. Mitochondrion.
Tissue expression
Expressed in heart, kidney, liver, lung, pancreas, and placenta, but not in skeletal muscle.
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