Immunogen
Synthesized peptide derived from human SCLY AA range: 367-417
Specificity
This antibody detects endogenous levels of SCLY at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008],
Function
catalytic activity:L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor.,cofactor:Pyridoxal phosphate.,function:Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.,induction:Up-regulated in acute glomerulonephritis. Regulated by AP-1.,similarity:Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homodimer.,
Fields
>>Selenocompound metabolism;>>Metabolic pathways
Human protein sequence Database
Q96I15
Mouse protein sequence database
Q9JLI6
Rat protein sequence database
Q68FT9
Cellular localization
Cytoplasm, cytosol .
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