Immunogen
Synthesized peptide derived from human KRA59 AA range: 9-59
Specificity
This antibody detects endogenous levels of KRA59 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
developmental stage:At a late stage of fiber differentiation.,function:In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.,similarity:Belongs to the KRTAP type 5 family.,subunit:Interacts with hair keratins.,tissue specificity:Restricted to hair root, not detected in any other tissues. Expressed in cuticle layers of differentiating hair follicles.,
Gene Name
KRTAP5-9 KAP5.9 KRN1 KRTAP5.9 UHSK1
Human protein sequence Database
P26371
Mouse protein sequence database
Rat protein sequence database
Cellular localization
keratin filament,
Tissue expression
Restricted to hair root, not detected in any other tissues. Expressed in cuticle layers of differentiating hair follicles.