Immunogen
Synthesized peptide derived from human TSSP AA range: 50-100
Specificity
This antibody detects endogenous levels of TSSP at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008],
Function
developmental stage:Expressed in fetal thymus.,function:Protease that may play a role in T-cell development.,similarity:Belongs to the peptidase S28 family.,subcellular location:Vesicular, either lysosomal or endosomal.,tissue specificity:Expressed predominantly in cortical thymic epithelial cells.,
Human protein sequence Database
Q9NQE7
Mouse protein sequence database
Q9QXE5
Rat protein sequence database
Cellular localization
Cytoplasmic vesicle. Vesicular, either lysosomal or endosomal.
Tissue expression
Expressed predominantly in cortical thymic epithelial cells.