Immunogen
Synthesized peptide derived from human ATS3 AA range: 600-650
Specificity
This antibody detects endogenous levels of ATS3 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016],
Function
caution:Has sometimes been referred to as ADAMTS4.,cofactor:Binds 1 zinc ion per subunit.,domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,function:Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 4 TSP type-1 domains.,tissue specificity:Found in cartilage and skin.,
Gene Name
ADAMTS3 KIAA0366
Human protein sequence Database
O15072
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted . Secreted, extracellular space, extracellular matrix .
Tissue expression
Found in cartilage and skin.
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