Immunogen
Synthesized peptide derived from human OSB11 AA range: 180-230
Specificity
This antibody detects endogenous levels of OSB11 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008],
Function
similarity:Belongs to the OSBP family.,similarity:Contains 1 PH domain.,tissue specificity:Widely expressed.,
Gene Name
OSBPL11 ORP11 OSBP12
Human protein sequence Database
Q9BXB4
Mouse protein sequence database
Q8CI95
Rat protein sequence database
Cellular localization
Late endosome membrane . Golgi apparatus, trans-Golgi network membrane . Localizes at the Golgi-late endosome interface.
Tissue expression
Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin (PubMed:20599956). Present at low levels in subcutaneous and visceral adipose tissue (at protein level)(PubMed:23028956).
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