Immunogen
Synthesized peptide derived from human MAGI3 AA range: 927-977
Specificity
This antibody detects endogenous levels of MAGI3 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.,miscellaneous:MAGI3 PDZ domains are used to design peptide ligands that bind and inhibit PDZ domains.,PTM:Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex.,sequence caution:Translation N-terminally
Fields
>>Rap1 signaling pathway
Human protein sequence Database
Q5TCQ9
Mouse protein sequence database
Q9EQJ9
Rat protein sequence database
Q9JK71
Cellular localization
Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Nucleus . Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions (By similarity). .
Tissue expression
Widely expressed.
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