Immunogen
Synthesized peptide derived from human BAIP3 AA range: 248-298
Specificity
This antibody detects endogenous levels of BAIP3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This p53-target gene encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. It interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. This protein also contains two C2 domains, which are often found in proteins involved in signal transduction or membrane trafficking. Its expression pattern and similarity to other proteins suggest that it may be involved in synaptic functions. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010],
Function
similarity:Contains 1 MHD1 (MUNC13 homology domain 1) domain.,similarity:Contains 1 MHD2 (MUNC13 homology domain 2) domain.,similarity:Contains 2 C2 domains.,subunit:Interacts with BAI1.,tissue specificity:Predominantly expressed in brain.,
Gene Name
BAIAP3 KIAA0734
Fields
>>Transcriptional misregulation in cancer
Human protein sequence Database
O94812
Mouse protein sequence database
Q80TT2
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol . Recycling endosome membrane ; Peripheral membrane protein . Late endosome membrane ; Peripheral membrane protein . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein . Rapidly recruited to the plasma membrane and to Golgi structures in response to increased intracellular calcium concentration. .
Tissue expression
Predominantly expressed in brain (PubMed:9790924). Also expressed in nonneural tissues such as breast and testes epithelium (PubMed:12498718).
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