Immunogen
Synthesized peptide derived from human PHF11 AA range: 232-282
Specificity
This antibody detects endogenous levels of PHF11 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein containing a PHD (plant homeodomain) type zinc finger. This gene has been identified in some studies as a candidate gene for asthma. Naturally-occurring readthrough transcription may occur from the upstream SETDB2 (SET domain bifurcated 2) gene to this locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
Function
alternative products:A number of isoforms may be produced,polymorphism:Variation in PHF11 seems to be associated with propensity to atopy and asthma.,similarity:Contains 1 PHD-type zinc finger.,subunit:Interacts with BRCA1.,tissue specificity:Expressed in all normal tissues tested, including lung, testis, small intestine, breast, liver and placenta.,
Human protein sequence Database
Q9UIL8
Mouse protein sequence database
Q8BVM9
Rat protein sequence database
Q5I0E2
Cellular localization
Nucleus .
Tissue expression
Highly expressed in T and B-cells, as well as natural killer and mature dendritic cells. Expressed at higher levels in Th1 as compared to Th2 cells. Expressed at low levels in all normal tissues tested, including lung, testis, small intestine, breast, liver and placenta.
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