Immunogen
Synthesized peptide derived from human G3ST3 AA range: 191-241
Specificity
This antibody detects endogenous levels of G3ST3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3. [provided by RefSeq, Jul 2008],
Function
cofactor:Magnesium.,function:Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc.,online information:GlycoGene database,pathway:Protein modification; carbohydrate sulfation.,similarity:Belongs to the galactose-3-O-sulfotransferase family.,tissue specificity:Highly expressed in thyroid, brain, kidney, heart and spinal cord.,
Human protein sequence Database
Q96A11
Mouse protein sequence database
P61315
Rat protein sequence database
Cellular localization
Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein .
Tissue expression
Highly expressed in thyroid, brain, kidney, heart and spinal cord.