Immunogen
Synthesized peptide derived from human PRAF3 AA range: 120-170
Specificity
This antibody detects endogenous levels of PRAF3 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008],
Function
function:Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic.,induction:By methyl-beta-cyclodextrin (By similarity). Up-regulated upon induced differentiation and in heat stress.,similarity:Belongs to the PRA1 family.,subcellular location:Also exists as a soluble form in the cytoplasm. Associated with microtubules.,subunit:Forms multimers. Binds to prenylated RAB1A and RAB3A, to the neuronal glutamate transporter SLC1A1/EAAC1, and to the ADP-ribosylation like factor ARL6, a member of the Ras superfamily. Does not bind to VAMP2.,
Gene Name
ARL6IP5 DERP11 JWA PRA2 PRAF3 HSPC127
Human protein sequence Database
O75915
Mouse protein sequence database
Q8R5J9
Rat protein sequence database
Q9ES40
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasm . Cytoplasm, cytoskeleton . Also exists as a soluble form in the cytoplasm. Associated with microtubules. .
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