Immunogen
Synthesized peptide derived from human SH3G1 AA range: 112-162
Specificity
This antibody detects endogenous levels of SH3G1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],
Function
disease:In some cases of acute leukemia, a translocation results in the formation of a MLL-EEN fusion gene.,domain:An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.,function:Implicated in endocytosis. May recruit other proteins to membranes with high curvature.,similarity:Belongs to the endophilin family.,similarity:Contains 1 BAR domain.,similarity:Contains 1 SH3 domain.,subcellular location:Associated with postsynaptic endosomes in hippocampal neurons.,subunit:Interacts with ARC (By similarity). Interacts with SYNJ1 and DNM1. Interacts with PDCD6IP.,tissue specificity:Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.,
Gene Name
SH3GL1 CNSA1 SH3D2B
Human protein sequence Database
Q99961
Mouse protein sequence database
Q62419
Rat protein sequence database
O35964
Cellular localization
Cytoplasm . Early endosome membrane ; Peripheral membrane protein . Cell projection, podosome . Associated with postsynaptic endosomes in hippocampal neurons. .
Tissue expression
Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.
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