Immunogen
Synthesized peptide derived from human CYH4 AA range: 150-200
Specificity
This antibody detects endogenous levels of CYH4 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015],
Function
function:Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of GDP with GTP.,similarity:Contains 1 PH domain.,similarity:Contains 1 SEC7 domain.,tissue specificity:Expressed predominantly in peripheral blood leukocytes.,
Gene Name
CYTH4 CYT4 PSCD4
Fields
>>Phospholipase D signaling pathway;>>Endocytosis;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Salmonella infection
Human protein sequence Database
Q9UIA0
Mouse protein sequence database
Q80YW0
Rat protein sequence database
Cellular localization
Cell membrane ; Peripheral membrane protein .
Tissue expression
Expressed predominantly in peripheral blood leukocytes.
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