Immunogen
Synthesized peptide derived from human WDR82 AA range: 219-269
Specificity
This antibody detects endogenous levels of WDR82 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010],
Function
caution:The gene encoding this protein shares one overlapping exon with TMEM113.,function:Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3.,similarity:Belongs to the WD repeat SWD2 family.,similarity:Contains 6 WD repeats.,subunit:Interacts with CUL4B. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1.,
Gene Name
WDR82 WDR82A UNQ9342/PRO34047
Fields
>>mRNA surveillance pathway
Human protein sequence Database
Q6UXN9
Mouse protein sequence database
Q8BFQ4
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Associates with chromatin (PubMed:20516061). Recruited at sites of high RNA polymerase II occupancy (By similarity). .
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