Immunogen
Synthesized peptide derived from human MACF1 AA range: 5623-5673
Specificity
This antibody detects endogenous levels of human MACF1
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Gene Name
MACF1 ABP620 ACF7 KIAA0465 KIAA1251
Protein name
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)
Human protein sequence Database
Q9UPN3
Mouse protein sequence database
Q9QXZ0
Rat protein sequence database
D3ZHV2
Cellular localization
[Isoform 2]: Cytoplasm, cytoskeleton . Cytoplasm . Golgi apparatus . Cell membrane . Cell projection, ruffle membrane . The phosphorylated form is found in the cytoplasm while the non-phosphorylated form associates with the microtubules (By similarity). Localizes to the tips of microtubules (PubMed:27693509). Associated with the minus-end of microtubules via interaction with CAMSAP3 (PubMed:27693509). APC controls its localization to the cell membrane which is critical for its function in microtubule stabilization (PubMed:20937854). .; [Isoform 1]: Cytoplasm . Golgi apparatus . Localizes to the tips of microtubules. .
Tissue expression
Isoform 2: Ubiquitously expressed. Isoform 1: Expressed in cell lines NCI-H460, A-549 and HaCaT. Isoform 4: Expressed in heart, lung, pituitary and placenta, not found in brain, kidney, liver, pancreas or skeletal muscle.
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