Immunogen
Synthesized peptide derived from human KCND3 AA range: 91-141
Specificity
This antibody detects endogenous levels of human KCND3
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Protein name
Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3)
Fields
>>Spinocerebellar ataxia
Human protein sequence Database
Q9UK17
Mouse protein sequence database
Q9Z0V1
Rat protein sequence database
Q62897
Cellular localization
Cell membrane ; Multi-pass membrane protein . Cell membrane, sarcolemma ; Multi-pass membrane protein . Cell projection, dendrite . Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression. .
Tissue expression
Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas.