Immunogen
Synthesized peptide derived from human GRP4 AA range: 487-537
Specificity
This antibody detects endogenous levels of human GRP4
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Protein name
RAS guanyl-releasing protein 4
Fields
>>MAPK signaling pathway;>>Ras signaling pathway;>>Pathways in cancer
Human protein sequence Database
Q8TDF6
Mouse protein sequence database
Q8BTM9
Rat protein sequence database
Q8R5I4
Cellular localization
Cytoplasm. Cell membrane. Recruited to membranes upon activation by DAG.
Tissue expression
Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.
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