Molecular weight (DA)
82kD
Immunogen
Synthesized peptide derived from human PHEX
Specificity
This antibody detects endogenous levels of PHEX at Human, Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity . Cleaves ASARM peptides between Ser and Glu or Asp residues . Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide . Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides . Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation .
Protein name
Phosphate-regulating neutral endopeptidase (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (Vitamin D-resistant hypophosphatemic rickets protein) (X-linked hypophosphatemia protein) (HYP)
Human protein sequence Database
P78562
Mouse protein sequence database
P70669
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type II membrane protein .
Tissue expression
Specifically expressed in ovary (PubMed:9070861). Expressed at low levels in kidney (PubMed:9070861).
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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