Molecular weight (DA)
78kD
Immunogen
Recombinant Protein of ATG7
Specificity
The antibody detects endogenous ATG7 protein
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-300,WB 1:500-2000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
Function
domain:The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12.,function:Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy.,similarity:Belongs to the ATG7 family.,subunit:Homodimer (By similarity). Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.,tissue specificity:Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.,
Protein name
Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein)
Other name
Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7;Autophagy-related protein 7;APG7-like;hAGP7;Ubiquitin-activating enzyme E1-like protein)
Fields
>>Autophagy - other;>>Autophagy - animal;>>Ferroptosis;>>Neutrophil extracellular trap formation
Human protein sequence Database
O95352
Mouse protein sequence database
Q9D906
Rat protein sequence database
Q641Y5
Cellular localization
Cytoplasm . Preautophagosomal structure . Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. .
Tissue expression
Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.
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