Molecular weight (DA)
68kD
Immunogen
Synthesized phosho peptide around human DNAJC2 and MPP11 (Ser47)
Specificity
This antibody detects endogenous levels of Human Mouse Rat DNAJC2/MPP11 (phospho-Ser47)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008],
Function
PTM:Phosphorylated in M (mitotic) phase.,similarity:Contains 1 J domain.,similarity:Contains 2 SANT domains.,
Gene Name
DNAJC2 MPHOSPH11 MPP11 ZRF1
Protein name
DNAJC2/MPP11 (Ser47)
Other name
DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1)
Human protein sequence Database
Q99543
Mouse protein sequence database
P54103
Rat protein sequence database
Q7TQ20
Cellular localization
Nucleus . Cytoplasm, cytosol .
Tissue expression
Widely expressed.
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