Molecular weight (DA)
56-70kD
Immunogen
Synthesized phosho peptide around human RIP3 (Ser227)
Specificity
This antibody detects endogenous levels of Human RIP3 (phospho-Ser227)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Promotes apoptosis.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex.,tissue specificity:Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.,
Protein name
RIP3 (Ser227)
Other name
Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3)
Fields
>>Necroptosis;>>NOD-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway;>>TNF signaling pathway;>>Salmonella infection
Human protein sequence Database
Q9Y572
Mouse protein sequence database
Q9QZL0
Rat protein sequence database
Q9Z2P5
Cellular localization
Cytoplasm, cytosol . Nucleus . Mainly cytoplasmic. Present in the nucleus in response to influenza A virus (IAV) infection. .
Tissue expression
Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. ; [Isoform 3]: Expression is significantly increased in colon and lung cancers.
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