Molecular weight (DA)
69kD
Immunogen
Synthesized peptide derived from human PDE6G (Phospho Thr22)
Specificity
This antibody detects endogenous levels of Human, Mouse PDE6G (Phospho Thr22)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009],
Function
catalytic activity:Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.,function:Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the rod/cone cGMP-PDE gamma subunit family.,subunit:Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.,
Protein name
PDE6G (Phospho Thr22)
Other name
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (GMP-PDE gamma;EC 3.1.4.35)
Fields
>>Purine metabolism;>>Metabolic pathways;>>Phototransduction
Human protein sequence Database
P18545
Mouse protein sequence database
P09174
Rat protein sequence database
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