Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human QIK/QSK (Phospho-Thr175/163)
Specificity
This antibody detects endogenous levels of QIK/QSK (Phospho-Thr175/163) at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, and 0.114% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subunit:Interacts with and phosphorylates TORC2/CRTC2.,
Gene Name
SIK2 KIAA0781 QIK SNF1LK2
Protein name
QIK/QSK (Phospho-Thr175/163)
Other name
Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)
Fields
>>Glucagon signaling pathway
Human protein sequence Database
Q9H0K1
Mouse protein sequence database
Q8CFH6
Rat protein sequence database
Cellular localization
Cytoplasm . Endoplasmic reticulum membrane .
Tissue expression
Brain,Colon,Lung,Testis,
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