Immunogen
Synthesized peptide derived from human TIE1 (Phospho-Tyr1117)
Specificity
This antibody detects endogenous levels of TIE1 (Phospho-Tyr1117) at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, and 0.158% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],
Function
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Probable protein tyrosine-kinase transmembrane receptor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 3 EGF-like domains.,similarity:Contains 3 fibronectin type-III domains.,tissue specificity:Specifically expressed in developing vascular endothelial cells.,
Protein name
TIE1 (Phospho-Tyr1117)
Other name
Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1)
Human protein sequence Database
P35590
Mouse protein sequence database
Q06806
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein .
Tissue expression
Specifically expressed in developing vascular endothelial cells.
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