Immunogen
Synthesized peptide derived from human HSP105 (Phospho-Ser809)
Specificity
This antibody detects endogenous levels of HSP105 (Phospho-Ser809) at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, and 0.218% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.,PTM:Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.,similarity:Belongs to the heat shock protein 70 family.,subunit:Interacts with HSPA8/HSC70.,tissue specificity:Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.,
Gene Name
HSPH1 HSP105 HSP110 KIAA0201
Protein name
HSP105 (Phospho-Ser809)
Other name
Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein)
Fields
>>Protein processing in endoplasmic reticulum
Human protein sequence Database
Q92598
Mouse protein sequence database
Q61699
Rat protein sequence database
Q66HA8
Cellular localization
Cytoplasm .
Tissue expression
Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.
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