Molecular weight (DA)
15kD
Immunogen
Synthetic peptide from human protein at AA range: 380-420
Specificity
The antibody detects endogenous Tubulin α
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000, ELISA 1:10000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.
Function
disease:Defects in TUBA1A are the cause of lissencephaly type 3 (LIS3) [MIM:611603]. LIS is characterized by a smooth brain surface due to the absence (agyria) or reduction (pachygyria) of surface convolutions. It is often associated with psychomotor retardation and seizures. LIS3 features include agyria or pachygyria or laminar heterotopia, severe mental retardation, motor delay, variable presence of seizures, and abnormalities of corpus callosum, hippocampus, cerebellar vermis and brainstem.,function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,PTM:Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), resp
Protein name
Tubulin alpha
Other name
Alpha-tubulin 1 antibody
ALS22 antibody
B ALPHA 1 antibody
bA408E5.3 antibody
H2 ALPHA antibody
Hum a tub1 antibody
Hum a tub2 antibody
LIS3 antibody
MGC171407 antibody
MGC55332 antibody
TBA4A_HUMAN antibody
Testis-specific alpha-tubulin antibody
TUBA1 antibody
TUBA1A antibody
tuba1l antibody
Tuba4a antibody
Tubulin alpha 1 chain antibody
Tubulin alpha antibody
Tubulin alpha-1 chain antibody
tubulin alpha-1B chain antibody
Tubulin alpha-4A chain antibody
Tubulin H2-alpha antibody
Tubulin, alpha 1 (testis specific) antibody
tubulin, alpha 1, like antibody
Tubulin, alpha 4a antibody
Tubulin, alpha, testis-specific antibody
Tubulin, alpha-1 antibody
Fields
>>Phagosome;>>Apoptosis;>>Tight junction;>>Gap junction;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Pathogenic Escherichia coli infection;>>Salmonella infection
Human gene ID
7846/10376/84790/113457/112714/7277
Human protein sequence Database
Q71U36/P68363/Q9BQE3/Q13748/P68366/Q9NY65
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton.
Tissue expression
Expressed at a high level in fetal brain.
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