Immunogen
Synthetic peptide from human protein at AA range: 180-230
Specificity
The antibody detects endogenous NT-3
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008],
Function
function:Seems to promotes the survival of visceral and proprioceptive sensory neurons.,polymorphism:Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia. This does not seem to be the case.,similarity:Belongs to the NGF-beta family.,tissue specificity:Brain and peripheral tissues.,
Protein name
Neurotrophin-3 (NT-3) (HDNF) (Nerve growth factor 2) (NGF-2) (Neurotrophic factor)
Other name
Neurotrophin-3 (NT-3;HDNF;Nerve growth factor 2;NGF-2;Neurotrophic factor)
Fields
>>MAPK signaling pathway;>>Ras signaling pathway;>>PI3K-Akt signaling pathway;>>Neurotrophin signaling pathway
Human protein sequence Database
P20783
Mouse protein sequence database
P20181
Rat protein sequence database
P18280
Cellular localization
Secreted.
Tissue expression
Brain and peripheral tissues.
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