Immunogen
Synthetic peptide from human protein at AA range: 40-100
Specificity
The antibody detects endogenous HLA-DMβ
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008],
Function
domain:The YXXZ (Tyr-Xaa-Xaa-Zaa, where Zaa is a hydrophobic residue) motif mediates the targeting to the lysosomal compartments.,function:Plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides.,polymorphism:The following alleles of DMB are known: DMB*0101, DMB*0102, DMB*0103, DMB*0104 (DMB3.4), DMB*0105 and DMB*0106. The sequence shown is that of DMB*0101.,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subcellular location:Localizes to late endocytic compartment. Associates with lysosome membranes.,subunit:Heterodimer of an alpha chain (DMA) and a beta chain (DMB).,
Gene Name
HLA-DMB DMB RING7
Protein name
HLA class II histocompatibility antigen, DM beta chain (MHC class II antigen DMB) (Really interesting new gene 7 protein)
Other name
HLA class II histocompatibility antigen, DM beta chain (MHC class II antigen DMB;Really interesting new gene 7 protein)
Fields
>>Phagosome;>>Cell adhesion molecules;>>Antigen processing and presentation;>>Hematopoietic cell lineage;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>Intestinal immune network for IgA production;>>Type I diabetes mellitus;>>Leishmaniasis;>>Toxoplasmosis;>>Staphylococcus aureus infection;>>Tuberculosis;>>Influenza A;>>Human T-cell leukemia virus 1 infection;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Asthma;>>Autoimmune thyroid disease;>>Inflammatory bowel disease;>>Systemic lupus erythematosus;>>Rheumatoid arthritis;>>Allograft rejection;>>Graft-versus-host disease;>>Viral myocarditis
Human protein sequence Database
P28068
Mouse protein sequence database
P35737
Rat protein sequence database
Cellular localization
Late endosome membrane ; Single-pass type I membrane protein . Lysosome membrane ; Single-pass type I membrane protein . Localizes to late endocytic compartment. Associates with lysosome membranes.
Tissue expression
Blood,Lymph,Plasma,Spleen,
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