Immunogen
Synthetic peptide from human protein at AA range: 141-190
Specificity
The antibody detects endogenous CD300a
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
CD300a molecule(CD300A) Homo sapiens This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012],
Function
function:Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.,PTM:Phosphorylated on tyrosine.,similarity:Belongs to the CD300 family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Upon tyrosine-phosphorylation, interacts with PTN6/SHP-1 and PTPN11/SHP-2 and INPP5D.,tissue specificity:Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.,
Gene Name
CD300A CMRF35H IGSF12 HSPC083
Protein name
CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IR
Other name
CMRF35-like molecule 8 (CLM-8;CD300 antigen-like family member A;CMRF-35-H9;CMRF35-H9;CMRF35-H;IRC1/IRC2;Immunoglobulin superfamily member 12;IgSF12;Inhibitory receptor protein 60;IRp60;NK inhibitory receptor;CD antigen CD300a)
Human protein sequence Database
Q9UGN4
Mouse protein sequence database
Q6SJQ0
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein .
Tissue expression
Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.
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