Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human CGT
Specificity
This antibody detects endogenous levels of human CGT
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
UDP glycosyltransferase 8(UGT8) Homo sapiens The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011],
Function
catalytic activity:UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine.,function:Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.,online information:2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor,pathway:Sphingolipid metabolism; galactosylceramide biosynthesis.,similarity:Belongs to the UDP-glycosyltransferase family.,
Other name
2-hydroxyacylsphingosine 1-beta-galactosyltransferase (EC 2.4.1.45;Ceramide UDP-galactosyltransferase;Cerebroside synthase;UDP-galactose-ceramide galactosyltransferase)
Fields
>>Ether lipid metabolism;>>Sphingolipid metabolism;>>Metabolic pathways
Human protein sequence Database
Q16880
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane ; Single-pass membrane protein . Endoplasmic reticulum .
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