Immunogen
Synthesized peptide derived from human APOC1 AA range: 1-50
Specificity
This antibody detects endogenous levels of human APOC1
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA(peptide)1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016],
Function
function:Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein.,miscellaneous:Apo-CI makes up about 10% of the protein of the VLDL (very low density lipoprotein) and 2% of that of HDL (high density lipoprotein).,online information:Apolipoprotein C1 entry,similarity:Belongs to the apolipoprotein C1 family.,tissue specificity:Synthesized mainly in liver and to a minor degree in intestine. Secreted in plasma.,
Other name
Apolipoprotein C-I (Apo-CIB;ApoC-IB;Apolipoprotein C1) [Cleaved into: Truncated apolipoprotein C-I (Apo-CIB';ApoC-IB')]
Fields
>>Cholesterol metabolism
Human protein sequence Database
P02654
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen.
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