Immunogen
Synthesized peptide derived from human BRD1 AA range: 399-449
Specificity
This antibody detects endogenous levels of BRD1 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schozophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015],
Function
function:Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.,similarity:Contains 1 bromo domain.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 PWWP domain.,subunit:Component of the MOZ/MORF composed at least of ING5, MYST3/MOZ, MYST4/MORF and one of BRPF1, BRD1/BRPF2 and BRPF3.,tissue specificity:Highly expressed in testis.,
Human protein sequence Database
O95696
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Localizes to transcription start sites. .
Tissue expression
Highly expressed in testis.
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