Immunogen
Synthesized peptide derived from human APBB3 AA range: 403-453
Specificity
This antibody detects endogenous levels of APBB3 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:May modulate the internalization of beta-amyloid precursor protein.,similarity:Contains 1 WW domain.,similarity:Contains 2 PID domains.,subunit:Binds to the intracellular domain of the beta-amyloid precursor protein. Also bind to APP-like proteins.,tissue specificity:Expressed in various tissues.,
Human protein sequence Database
O95704
Mouse protein sequence database
Q8R1C9
Rat protein sequence database
O35827
Cellular localization
Cytoplasm . Nucleus .; [Isoform I-214]: Nucleus.; [Isoform I-245]: Nucleus.
Tissue expression
Expressed in various tissues, highest expression in brain.
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