Immunogen
Synthesized peptide derived from human DGLB AA range: 616-666
Specificity
This antibody detects endogenous levels of DGLB at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
cofactor:Calcium.,enzyme regulation:Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.,function:Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.,similarity:Belongs to the AB hydrolase superfamily. Lipase family.,
Fields
>>Retrograde endocannabinoid signaling;>>Aldosterone synthesis and secretion
Human protein sequence Database
Q8NCG7
Mouse protein sequence database
Q91WC9
Rat protein sequence database
P0C1S9
Cellular localization
Cell membrane ; Multi-pass membrane protein .