Immunogen
Synthesized peptide derived from human FBX46 AA range: 67-117
Specificity
This antibody detects endogenous levels of FBX46 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008],
Function
caution:The region from 1 to 163 was deduced from the genomic sequence and ESTs by similarity to the mouse sequence.,function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,subunit:Interacts with SKP1A and CUL1.,
Gene Name
FBXO46 FBX46 FBXO34L
Human protein sequence Database
Q6PJ61
Mouse protein sequence database
Q8BG80
Rat protein sequence database
Q4KLY2