Immunogen
Synthesized peptide derived from human HDA11 AA range: 170-220
Specificity
This antibody detects endogenous levels of HDA11 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009],
Function
catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,miscellaneous:Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.,sequence caution:Translated as Gln.,similarity:Belongs to the histone deacetylase family.,subcellular location:Predominantly nuclear.,subunit:Interacts with HDAC6.,tissue specificity:Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.,
Fields
>>Neutrophil extracellular trap formation;>>Alcoholism;>>Viral carcinogenesis
Human protein sequence Database
Q96DB2
Mouse protein sequence database
Q91WA3
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.
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