Molecular weight (DA)
63kD
Immunogen
Synthesized peptide derived from human OTUD5
Specificity
This antibody detects endogenous levels of OTUD5 at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 .
Protein name
OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA)
Human protein sequence Database
Q96G74
Mouse protein sequence database
Q3U2S4
Rat protein sequence database
Q2YDU3
Cellular localization
Nucleus .
Tissue expression
Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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