Immunogen
Synthesized peptide derived from human PA2GE AA range: 58-108
Specificity
This antibody detects endogenous levels of PA2GE at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
catalytic activity:Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.,cofactor:Binds 1 calcium ion per subunit.,function:PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.,similarity:Belongs to the phospholipase A2 family.,tissue specificity:Restricted to the brain, heart, lung, and placenta.,
Fields
>>Glycerophospholipid metabolism;>>Ether lipid metabolism;>>Arachidonic acid metabolism;>>Linoleic acid metabolism;>>alpha-Linolenic acid metabolism;>>Metabolic pathways;>>Ras signaling pathway;>>Vascular smooth muscle contraction;>>Pancreatic secretion;>>Fat digestion and absorption
Human protein sequence Database
Q9NZK7
Mouse protein sequence database
Q9QUL3
Rat protein sequence database
Cellular localization
Secreted . Cytoplasm . Through binding to heparan sulfate proteoglycan, may be localized to cytoplasmic compartments enriched in anionic phospholipids. .
Tissue expression
Restricted to the brain, heart, lung, and placenta.
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