Immunogen
Synthesized peptide derived from human EXTL2 AA range: 141-191
Specificity
This antibody detects endogenous levels of EXTL2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
catalytic activity:UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan.,function:Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.,online information:Exostosin-like 2,online information:GlycoGene database,pathway:Glycan metabolism; heparan sulfate biosynthesis.,PTM:The soluble form derives from the membrane form by proteolytic processing.,similarity:Belongs to the glycosyltransferase 47 family.,subcellular location:A soluble form is found in the serum.,tissue specifi
Fields
>>Glycosaminoglycan biosynthesis - heparan sulfate / heparin;>>Metabolic pathways
Human protein sequence Database
Q9UBQ6
Mouse protein sequence database
Q9ES89
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Single-pass type II membrane protein .; [Processed exostosin-like 2]: Secreted. A soluble form is found in the serum.
Tissue expression
Ubiquitous.
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