Immunogen
Synthesized peptide derived from human CSTF3 AA range: 231-281
Specificity
This antibody detects endogenous levels of CSTF3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Function
function:One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.,similarity:Contains 9 HAT repeats.,subunit:Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF3 directly interacts with CSTF1 and CSTF2. Interacts with FIP1L1.,
Fields
>>mRNA surveillance pathway
Human protein sequence Database
Q12996
Mouse protein sequence database
Q99LI7
Rat protein sequence database
Cellular localization
Nucleus.
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