Immunogen
Synthesized peptide derived from human RINI AA range: 273-323
Specificity
This antibody detects endogenous levels of RINI at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010],
Function
function:Inhibitor of pancreatic RNase and angiogenin. May also function in the modulation of cellular activities.,PTM:At least 30 of the 32 cysteine residues are in the reduced form.,PTM:The N-terminus is blocked.,similarity:Contains 15 LRR (leucine-rich) repeats.,subunit:Forms a tight one-to-one complex with the RNase.,
Human protein sequence Database
P13489
Mouse protein sequence database
Q91VI7
Rat protein sequence database
P29315
Cellular localization
Cytoplasm.
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