Immunogen
Synthesized peptide derived from human CAR16 AA range: 101-151
Specificity
This antibody detects endogenous levels of CAR16 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.,induction:Down-regulated in patients suffering of Huntington disease.,similarity:Contains 1 CARD domain.,subunit:Homooligomer. Interacts with CASP1, CASP4, CARD8 and RIPK2.,tissue specificity:Widely expressed. Expressed at higher level in placenta, spleen, lymph
Gene Name
CARD16 COP COP1
Fields
>>NOD-like receptor signaling pathway
Human protein sequence Database
Q5EG05
Mouse protein sequence database
Rat protein sequence database
Tissue expression
Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.
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