Immunogen
Synthesized peptide derived from human AK1BA AA range: 124-174
Specificity
This antibody detects endogenous levels of AK1BA at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008],
Function
enzyme regulation:Inhibited by tolrestat.,function:Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.,similarity:Belongs to the aldo/keto reductase family.,tissue specificity:Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.,
Gene Name
AKR1B10 AKR1B11
Fields
>>Pentose and glucuronate interconversions;>>Fructose and mannose metabolism;>>Galactose metabolism;>>Glycerolipid metabolism;>>Folate biosynthesis;>>Metabolic pathways
Human protein sequence Database
O60218
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Lysosome . Secreted . Secreted through a lysosome-mediated non-classical pathway.
Tissue expression
Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
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