Molecular weight (DA)
42kD
Immunogen
Purified recombinant human SIRT6 protein expressed in E.coli.
Specificity
This antibody detects endogenous levels of SIRT6 and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
wb 1:500 IF/icc 1:100
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],
Function
catalytic activity:NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.,catalytic activity:NADP(+) + protein-L-arginine = nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine.,cofactor:Binds 1 zinc ion per subunit.,PTM:ADP-ribosylated (-auto).,similarity:Belongs to the sirtuin family.,similarity:Contains 1 deacetylase sirtuin-type domain.,subcellular location:Predominantly nuclear.,
Other name
2810449N18Rik;AI043036;Mono ADP ribosyltransferase sirtuin 6;NAD-dependent protein deacetylase sirtuin-6;Regulatory protein SIR2 homolog 6;Regulatory protein SIR2 homolog;SIR2 like 6;SIR2 like protein 6;Sir2 related protein type 6;SIR2-like protein 6;SIR2
Fields
>>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Thermogenesis;>>Central carbon metabolism in cancer
Human protein sequence Database
Q8N6T7
Mouse protein sequence database
P59941
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Chromosome, telomere . Endoplasmic reticulum . Predominantly nuclear (PubMed:18337721). Associated with pericentric heterochromatin and telomeric heterochromatin regions (PubMed:18337721, PubMed:27043296). Localizes to DNA damage sites: directly recognizes and binds double-strand breaks (DSBs) sites via a tunnel-like structure that has high affinity for DSBs (PubMed:21680843, PubMed:23911928, PubMed:27568560, PubMed:31995034, PubMed:32538779). A fraction localizes to the endoplasmic reticulum (PubMed:23552949). .
Tissue expression
Blood,Eye,Lung,Placenta,Spleen,Teratocarcinoma,
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