Immunogen
Synthesized peptide derived from human FADS3 AA range: 60-110
Specificity
This antibody detects endogenous levels of FADS3 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008],
Function
domain:The histidine box domains may contain the active site and/or be involved in metal ion binding.,similarity:Belongs to the fatty acid desaturase family.,similarity:Contains 1 cytochrome b5 heme-binding domain.,tissue specificity:Has been found in heart, liver, lung, uterus, and brainstem.,
Human protein sequence Database
Q9Y5Q0
Mouse protein sequence database
Q9JJE7
Rat protein sequence database
Q8K1P9
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue expression
Highly expressed in various organs and tissues including liver, kidney, brain, lung, pancreas, testis, ovary and skeletal muscle (at protein level).
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