Immunogen
Synthesized peptide derived from human PLP2 AA range: 56-106
Specificity
This antibody detects endogenous levels of PLP2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked mental retardation. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010],
Function
function:May play a role in cell differentiation in the intestinal epithelium.,similarity:Contains 1 MARVEL domain.,tissue specificity:Enriched in colonic mucosa. The expression of A4 follows a gradient along the crypto-villus axis with the most abundant message occurring in the lower half of the crypt.,
Human protein sequence Database
Q04941
Mouse protein sequence database
Q9R1Q7
Rat protein sequence database
Q6P742
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Enriched in colonic mucosa. The expression of A4 follows a gradient along the crypto-villus axis with the most abundant message occurring in the lower half of the crypt.
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