Immunogen
Synthesized peptide derived from human GKN1 AA range: 47-97
Specificity
This antibody detects endogenous levels of GKN1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008],
Function
caution:It is uncertain whether Met-1 or Met-15 is the initiator.,function:Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.,similarity:Belongs to the gastrokine family.,similarity:Contains 1 BRICHOS domain.,tissue specificity:Expressed in stomach. No expression is detected in cancer tissue or gastric cancer cell lines.,
Gene Name
GKN1 AMP18 CA11 UNQ489/PRO1005
Human protein sequence Database
Q9NS71
Mouse protein sequence database
Q9CR36
Rat protein sequence database
Cellular localization
Secreted . Cytoplasmic granule . Golgi apparatus . Shows abundant granular cytoplasmic staining, with perinuclear accentuation suggestive of the Golgi apparatus. .
Tissue expression
Expressed in stomach (at protein level). No expression is detected in cancer tissue or gastric cancer cell lines.